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Article

The Ubiquitin Ligase Adaptor NDFIP1 Selectively Enforces a CD8+ T Cell Tolerance Checkpoint to High-Dose Antigen.

Cell reports - 17 Jul 2018

Wagle Mayura V, Marchingo Julia M, Howitt Jason, Tan Seong-Seng, Goodnow Christopher C, Parish Ian A

Abstract excerpt

Escape from peripheral tolerance checkpoints that control cytotoxic CD8+ T cells is important for cancer immunotherapy and autoimmunity, but pathways enforcing these checkpoints are mostly uncharted. We reveal that the HECT-type ubiquitin ligase activator, NDFIP1, enforces a cell-intrinsic CD8+ T cell checkpoint that desensitizes TCR signaling during in vivo exposure to high antigen levels. Ndfip1-deficient OT-I...

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Share to Antigens
Share to Autoantigens

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Clonal Anergy

Share to Dose-Response Relationship, Immunologic

Share to Immune Tolerance

Share to Intercellular Signaling Peptides and Proteins

Share to Pancreas

Share to Receptors, Antigen, T-Cell

Source

Open in PubMed Open full text

Identifiers

PMID: 30021156
DOI: 10.1016/j.celrep.2018.06.060
PMCID: PMC6112980

Genes

NDFIP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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