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Article

A role for the histone H2A deubiquitinase MYSM1 in maintenance of CD8+ T cells.

Immunology - 1 May 2017

Förster Michael, Boora Rupinder K, Petrov Jessica C, Fodil Nassima, Albanese Isabella, Kim Jamie, Gros Philippe, Nijnik Anastasia

Abstract excerpt

Several previous studies outlined the importance of the histone H2A deubiquitinase MYSM1 in the regulation of stem cell quiescence and haematopoiesis. In this study we investigated the role of MYSM1 in T-cell development. Using mouse models that allow conditional Mysm1 ablation at late stages of thymic development, we found that MYSM1 is intricately involved in the maintenance, activation and survival of CD8+ T...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28066899
DOI: 10.1111/imm.12710
PMCID: PMC5382346

Genes

MYSM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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