Article

SPOP Promotes Ubiquitination and Degradation of MyD88 to Suppress the Innate Immune Response

2019-11-05

Abstract excerpt

As a canonical adaptor for Toll-like receptor (TLR) family, MyD88 has crucial roles in host defence against infection of microbial pathogens and its dysregulation might induce autoimmune diseases. Here we demonstrate that the Cullin 3-based ubiquitin ligase adaptor SPOP recognizes the intermediate domain and degrades chMyD88 through the proteasome pathway. Knockdown or genetic ablation of chSPOP leads to aberrant...

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Literature Corpus work: 66e5b955-9766-5fc6-92d8-54deb298dfa6
DOI: 10.1101/831586

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