Genetic Inhibition of APOL1 Pore-Forming Function Prevents APOL1-Mediated Kidney Disease.

doi:10.1681/ASN.0000000000000219

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Article

Genetic Inhibition of APOL1 Pore-Forming Function Prevents APOL1-Mediated Kidney Disease.

Journal of the American Society of Nephrology : JASN - 1 Nov 2023

Hung Adriana M, Assimon Victoria A, Chen Hua-Chang, Yu Zhihong, Vlasschaert Caitlyn, Triozzi Jefferson L, Chan Helen, Wheless Lee, Wilson Otis, Shah Shailja C, Mack Taralynn, Thompson Trevor, Matheny Michael E, Chandrasekar Saranya, Mozaffari Sahar V, Chung Cecilia P, Tsao Philip, Susztak Katalin, Siew Edward D, Estrada Karol, Gaziano J Michael, Graham Robert R, Tao Ran, Hoek Maarten, Robinson-Cohen Cassianne, Green Eric M, Bick Alexander G

Abstract excerpt

SIGNIFICANCE STATEMENT: African Americans are at increased risk of CKD in part due to high-risk (HR) variants in the apolipoprotein L1 ( APOL1 ) gene, termed G1/G2. A different APOL1 variant, p.N264K , reduced the risk of CKD and ESKD among carriers of APOL1 HR variants to levels comparable with individuals with APOL1 low-risk variants in an analysis of 121,492 participants of African ancestry from the Million...

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PMID: 37798822
DOI: 10.1681/ASN.0000000000000219
PMCID: PMC10631602

Genes

APOL1
MVP

Variants

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