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Article

Genome-wide screen identifies peroxisomal role in APOL1 podocytopathy.

Kidney international - 1 Sept 2026

Kim Jiyoung, Karel Isaac Z, Song Huijuan, Dewalt Megan, Mondal Milon, Orwick Shelley, Buelow Daelynn R, Lee Kendyll, Brodsky Sergey V, Blissett Angie, Cocucci Ema, Baker Sharyn D, Lin Pei-Hui, Pabla Navjot S, Madhavan Sethu M

Abstract excerpt

INTRODUCTION: Risk variants G1 and G2 of APOL1 confer a markedly increased risk of chronic kidney disease (CKD) in individuals of African ancestry, yet disease expression requires secondary insults such as inflammation or hypoxia. How these stressors intersect with APOL1 risk variants to drive podocyte injury and cell death remains poorly defined. METHODS: To identify pathways that modify APOL1 variant-induced...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 42309203
DOI: 10.1016/j.kint.2026.04.037

Genes

APOL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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