Article
X-ray crystal structures of the type IVb secretion system DotB ATPases.
Protein science : a publication of the Protein Society - 1 Aug 2018
Prevost Marie S, Waksman Gabriel
Abstract excerpt
Human infections by the intracellular bacterial pathogen Legionella pneumophila result in a severe form of pneumonia, the Legionnaire's disease. L. pneumophila utilizes a Type IVb secretion (T4bS) system termed "dot/icm" to secrete protein effectors to the host cytoplasm. The dot/icm system is powered at least in part by a functionally critical AAA+ ATPase, a protein called DotB, thought to belong to the VirB11...
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