Apolipoprotein E-ε2 and Resistance to Atherosclerosis in Midlife: The PESA Observational Study.

doi:10.1161/CIRCRESAHA.123.323921

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Article

Apolipoprotein E-ε2 and Resistance to Atherosclerosis in Midlife: The PESA Observational Study.

Circulation research - 16 Feb 2024

Toribio-Fernández Raquel, Tristão-Pereira Catarina, Carlos Silla-Castro Juan, Callejas Sergio, Oliva Belen, Fernandez-Nueda Irene, Garcia-Lunar Ines, Perez-Herreras Cristina, María Ordovás José, Martin Pilar, Blanco-Kelly Fiona, Ayuso Carmen, Lara-Pezzi Enrique, Fernandez-Ortiz Antonio, Garcia-Alvarez Ana, Dopazo Ana, Sanchez-Cabo Fatima, Ibanez Borja, Cortes-Canteli Marta, Fuster Valentin

Abstract excerpt

BACKGROUND: APOE is a known genetic contributor to cardiovascular disease, but the differential role APOE alleles play in subclinical atherosclerosis remains unclear. METHODS: The PESA (Progression of Early Subclinical Atherosclerosis) is an observational cohort study that recruited 4184 middle-aged asymptomatic individuals to be screened for cardiovascular risk and multiterritorial subclinical atherosclerosis....

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PMID: 38258600
DOI: 10.1161/CIRCRESAHA.123.323921

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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