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APOE Genotype and Statin Response: Evidence From the UK Biobank and All of Us Program.

Clinical and translational science - 1 Aug 2025

Asiimwe Innocent G, Jorgensen Andrea L, Pirmohamed Munir

Abstract excerpt

APOE genotype may affect statin response. Using UK Biobank (UKB) and All of Us (AoU) data, we aimed to investigate associations between APOE genotype, statin use, and key health outcomes. Our analysis included UKB baseline data and linked mortality records (389,843-452,189 participants), and electronic health records (EHR) from 45,515 UKB and 35,562 AoU participants. Multivariable regression and Cox models...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40763922
DOI: 10.1111/cts.70314
PMCID: PMC12324813

Genes

APOE

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