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Article

GWAS for Lifespan and Decline in Climbing Ability in Flies upon Dietary Restriction Reveal decima as a Mediator of Insulin-like Peptide Production.

Current biology : CB - 20 Jul 2020

Wilson Kenneth A, Beck Jennifer N, Nelson Christopher S, Hilsabeck Tyler A, Promislow Daniel, Brem Rachel B, Kapahi Pankaj

Abstract excerpt

Dietary restriction (DR) is the most robust means to extend lifespan and delay age-related diseases across species. An underlying assumption in the aging field is that DR enhances both lifespan and physical activity through similar mechanisms, but this has not been rigorously tested in different genetic backgrounds. Furthermore, nutrient response genes responsible for lifespan extension or age-related decline in...

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Share to Animal Nutritional Physiological Phenomena
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 32502405
DOI: 10.1016/j.cub.2020.05.020
PMCID: PMC7375902

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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