Article
The role of genetic variation in shaping phenotypic responses to diet in aging Drosophila melanogaster.
Heredity - 1 Nov 2025
Bak Nikolaj Klausholt, Mackay Trudy F C, Morgante Fabio, Nielsen Kåre Lehmann, Nielsen Jeppe Lund, Kristensen Torsten Nygaard, Rohde Palle Duun
Abstract excerpt
Nutrition plays a central role in healthy living, however, extensive variability in individual responses to dietary interventions complicates our understanding of its effects. Here we present a comprehensive study utilizing the Drosophila Genetic Reference Panel (DGRP), investigating how genetic variation influences responses to diet and aging. We performed quantitative genetic analyses of the impact of reduced...
Topics
- Drosophila melanogaster
- Phenotype
- Genetic Variation
- Longevity
- Caloric Restriction
- Healthy Aging
- Locomotion
- Body Weight
- Genome-Wide Association Study
- Male
- Female