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Article

The role of genetic variation in shaping phenotypic responses to diet in aging Drosophila melanogaster.

Heredity - 1 Nov 2025

Bak Nikolaj Klausholt, Mackay Trudy F C, Morgante Fabio, Nielsen Kåre Lehmann, Nielsen Jeppe Lund, Kristensen Torsten Nygaard, Rohde Palle Duun

Abstract excerpt

Nutrition plays a central role in healthy living, however, extensive variability in individual responses to dietary interventions complicates our understanding of its effects. Here we present a comprehensive study utilizing the Drosophila Genetic Reference Panel (DGRP), investigating how genetic variation influences responses to diet and aging. We performed quantitative genetic analyses of the impact of reduced...

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Identifiers

PMID: 40993208
DOI: 10.1038/s41437-025-00797-3
PMCID: PMC12594875

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