Article
Genetic and metabolomic architecture of variation in diet restriction-mediated lifespan extension in Drosophila.
PLoS genetics - 1 Jul 2020
Jin Kelly, Wilson Kenneth A, Beck Jennifer N, Nelson Christopher S, Brownridge George W, Harrison Benjamin R, Djukovic Danijel, Raftery Daniel, Brem Rachel B, Yu Shiqing, Drton Mathias, Shojaie Ali, Kapahi Pankaj, Promislow Daniel
Abstract excerpt
In most organisms, dietary restriction (DR) increases lifespan. However, several studies have found that genotypes within the same species vary widely in how they respond to DR. To explore the mechanisms underlying this variation, we exposed 178 inbred Drosophila melanogaster lines to a DR or ad libitum (AL) diet, and measured a panel of 105 metabolites under both diets. Twenty four out of 105 metabolites were...
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