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Article

Systems biology approaches identify metabolic signatures of dietary lifespan and healthspan across species.

Nature communications - 29 Oct 2024

Hilsabeck Tyler A U, Narayan Vikram P, Wilson Kenneth A, Carrera Enrique M, Raftery Daniel, Promislow Daniel, Brem Rachel B, Campisi Judith, Kapahi Pankaj

Abstract excerpt

Dietary restriction (DR) is a potent method to enhance lifespan and healthspan, but individual responses are influenced by genetic variations. Understanding how metabolism-related genetic differences impact longevity and healthspan are unclear. To investigate this, we used metabolites as markers to reveal how different genotypes respond to diet to influence longevity and healthspan traits. We analyzed data from...

Topics

Longevity
Animals
Humans
Systems Biology
Male
Female
Drosophila melanogaster
Metabolomics
Caloric Restriction
Diet
Species Specificity

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Drosophila

Genetic Variation

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Identifiers

PMID: 39472442
DOI: 10.1038/s41467-024-52909-y
PMCID: PMC11522498

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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