Article
Genome-wide analysis in Drosophila reveals diet-by-gene interactions and uncovers diet-responsive genes.
G3 (Bethesda, Md.) - 27 Sept 2021
Francis Deanne, Ghazanfar Shila, Havula Essi, Krycer James R, Strbenac Dario, Senior Alistair, Minard Annabel Y, Geddes Thomas, Nelson Marin E, Weiss Fiona, Stöckli Jacqueline, Yang Jean Y H, James David E
Abstract excerpt
Genetic and environmental factors play a major role in metabolic health. However, they do not act in isolation, as a change in an environmental factor such as diet may exert different effects based on an individual's genotype. Here, we sought to understand how such gene-diet interactions influenced nutrient storage and utilization, a major determinant of metabolic disease. We subjected 178 inbred strains from the...
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