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Article

Longevity GWAS Using the Drosophila Genetic Reference Panel.

The journals of gerontology. Series A, Biological sciences and medical sciences - 1 Dec 2015

Ivanov Dobril K, Escott-Price Valentina, Ziehm Matthias, Magwire Michael M, Mackay Trudy F C, Partridge Linda, Thornton Janet M

Abstract excerpt

We used 197 Drosophila melanogaster Genetic Reference Panel (DGRP) lines to perform a genome-wide association analysis for virgin female lifespan, using ~2M common single nucleotide polymorphisms (SNPs). We found considerable genetic variation in lifespan in the DGRP, with a broad-sense heritability of 0.413. There was little power to detect signals at a genome-wide level in single-SNP and gene-based analyses....

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PMID: 25922346
DOI: 10.1093/gerona/glv047
PMCID: PMC4631106

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