Dietary restriction is evolutionarily conserved on the phenotypic and mechanistic level.

Abstract excerpt

The anti-ageing response to Dietary Restriction (DR) is thought to be mechanistically ancient, reasoning from its phenotypic conservation. However, DR is implemented differently across species and evidence for conserved mechanisms remains limited. Here, we tested longevity and fecundity in response to DR across eight different Drosophila species, finding that DR is, on balance, phenotypically conserved. Next, we...

Topics

• Animals
• Longevity
• Phenotype
• Caloric Restriction
• Fertility
• Drosophila
• Gene Expression Profiling