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Article

Nutrient-dependent control of RNA polymerase II elongation rate regulates specific gene expression programs by alternative polyadenylation.

Genes & development - 1 Jul 2020

Yague-Sanz Carlo, Vanrobaeys Yann, Fernandez Ronan, Duval Maxime, Larochelle Marc, Beaudoin Jude, Berro Julien, Labbé Simon, Jacques Pierre-Étienne, Bachand François

Abstract excerpt

Transcription by RNA polymerase II (RNAPII) is a dynamic process with frequent variations in the elongation rate. However, the physiological relevance of variations in RNAPII elongation kinetics has remained unclear. Here we show in yeast that a RNAPII mutant that reduces the transcription elongation rate causes widespread changes in alternative polyadenylation (APA). We unveil two mechanisms by which APA affects...

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Identifiers

PMID: 32499400
DOI: 10.1101/gad.337212.120
PMCID: PMC7328516

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