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Article

Elongation rate of RNA polymerase II affects pausing patterns across 3' UTRs.

The Journal of biological chemistry - 1 Nov 2023

Khitun Alexandra, Brion Christian, Moqtaderi Zarmik, Geisberg Joseph V, Churchman L Stirling, Struhl Kevin

Abstract excerpt

Yeast mRNAs are polyadenylated at multiple sites in their 3' untranslated regions (3' UTRs), and poly(A) site usage is regulated by the rate of transcriptional elongation by RNA polymerase II (Pol II). Slow Pol II derivatives favor upstream poly(A) sites, and fast Pol II derivatives favor downstream poly(A) sites. Transcriptional elongation and polyadenylation are linked at the nucleotide level, presumably...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37748648
DOI: 10.1016/j.jbc.2023.105289
PMCID: PMC10598743

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