Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic analysis of polyadenylation patterns reveals distinct classes of yeast genes and local chromatin effects on Pol II elongation.

Genetics - 6 May 2026

Moqtaderi Zarmik, Geisberg Joseph V, Struhl Kevin

Abstract excerpt

The poly(A) profile of a typical yeast gene comprises ∼50 poly(A) sites corresponding to distinct 3' mRNA isoforms. Poly(A) profiles are shifted upstream in strains with slow RNA polymerase II (Pol II) elongation rates resulting from Pol II mutations or from depletion of histone chaperones FACT or Spt6. Conversely, downstream-shifted poly(A) profiles occur in strains with fast Pol II elongation rates caused by...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromatin
Share to Genes, Fungal
Share to Polyadenylation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to RNA, Messenger

Share to RNA Polymerase II

Share to Saccharomyces cerevisiae

Share to Saccharomyces cerevisiae Proteins

Share to Transcriptional Elongation Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 41757456
DOI: 10.1093/genetics/iyag057
PMCID: PMC13147533

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic analysis of polyadenylation patterns reveals distinct classes of yeast genes and local chromatin effects on Pol II elongation.PMID 41757456Read ↗

In vivo evidence that defects in the transcriptional elongation factors RPB2, TFIIS, and SPT5 enhance upstream poly(A) site utilization.Semantic proximity Read ↗

Species-specific factors mediate extensive heterogeneity of mRNA 3' ends in yeasts.Semantic proximity Read ↗

Elongation rate of RNA polymerase II affects pausing patterns across 3' UTRs.Semantic proximity Read ↗

RNA polymerase mapping during stress responses reveals widespread nonproductive transcription in yeast.Semantic proximity Read ↗

Genome-Wide Analysis of PAPS1-Dependent Polyadenylation Identifies Novel Roles for Functionally Specialized Poly(A) Polymerases in Arabidopsis thaliana.Semantic proximity Read ↗

The distribution of active RNA polymerase II along the transcribed region is gene-specific and controlled by elongation factors.Semantic proximity Read ↗

Distinct roles of non-canonical poly(A) polymerases in RNA metabolism.Semantic proximity Read ↗

Conditional defect in mRNA 3' end processing caused by a mutation in the gene for poly(A) polymerase.Semantic proximity Read ↗

Spt5's central KOW domains and the Pol II stalk collaborate to regulate chromatin and 3'-end processing in Saccharomyces cerevisiae.Semantic proximity Read ↗

The PolyA tail length of yeast histone mRNAs varies during the cell cycle and is influenced by Sen1p and Rrp6p.Semantic proximity Read ↗

A quantitative, high-throughput reverse genetic screen reveals novel connections between Pre-mRNA splicing and 5' and 3' end transcript determinants.Semantic proximity Read ↗

Positive and negative regulation of poly(A) nuclease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.