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Article

Distinct roles of non-canonical poly(A) polymerases in RNA metabolism.

PLoS genetics - 1 Jul 2009

San Paolo Salvatore, Vanacova Stepanka, Schenk Luca, Scherrer Tanja, Blank Diana, Keller Walter, Gerber André P

Abstract excerpt

Trf4p and Trf5p are non-canonical poly(A) polymerases and are part of the heteromeric protein complexes TRAMP4 and TRAMP5 that promote the degradation of aberrant and short-lived RNA substrates by interacting with the nuclear exosome. To assess the level of functional redundancy between the paralogous Trf4 and Trf5 proteins and to investigate the role of the Trf4-dependent polyadenylation in vivo, we used DNA...

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Identifiers

PMID: 19593367
DOI: 10.1371/journal.pgen.1000555
PMCID: PMC2700272

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