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Article

Reprogramming of Acute Myeloid Leukemia Patients Cells: Harboring Cancer Mutations Requires Targeting of AML Hierarchy.

Stem cells translational medicine - 15 Jun 2023

Golubeva Diana, Porras Deanna P, Doyle Meaghan, Reid Jennifer C, Tanasijevic Borko, Boyd Allison L, Vojnits Kinga, Elrafie Amro, Qiao Amy, Bhatia Mickie

Abstract excerpt

Screening of primary patient acute myeloid leukemia (AML) cells is challenging based on intrinsic characteristics of human AML disease and patient-specific conditions required to sustain AML cells in culture. This is further complicated by inter- and intra-patient heterogeneity, and "contaminating" normal cells devoid of molecular AML mutations. Derivation of induced pluripotent stem cells (iPSCs) from human...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37226319
DOI: 10.1093/stcltm/szad022
PMCID: PMC10267577

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