Article
A Single Natural Variation Determines Cytosolic Ca2+-Mediated Hyperthermosensitivity of TRPA1s from Rattlesnakes and Boas.
Molecules and cells - 30 Jun 2020
Du Eun Jo, Kang KyeongJin
Abstract excerpt
Transient receptor potential ankyrin 1 from rattlesnakes (rsTRPA1) and boas (bTRPA1) was previously proposed to underlie thermo-sensitive infrared sensing based on transcript enrichment in infrared-sensing neurons and hyper-thermosensitivity expressed in Xenopus oocytes. It is unknown how these TRPA1s show thermosensitivities that overwhelm other thermoreceptors, and why rsTRPA1 is more thermosensitive than...
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