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Article

Requirement of extracellular Ca2+ binding to specific amino acids for heat-evoked activation of TRPA1.

The Journal of physiology - 15 Apr 2017

Kurganov Erkin, Saito Shigeru, Tanaka Saito Claire, Tominaga Makoto

Abstract excerpt

KEY POINTS: We found that extracellular Ca2+ , but not other divalent cations (Mg2+ and Ba2+ ) or intracellular Ca2+ , is involved in heat-evoked activation of green anole (ga) TRPA1. Heat-evoked activation of chicken (ch) and rat snake (rs) TRPA1 does not depend solely on extracellular Ca2+ . Neutralization of acidic amino acids on the outer surface of TRPA1 by extracellular Ca2+ is important for heat-evoked...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28194754
DOI: 10.1113/JP274083
PMCID: PMC5390868

Genes

TRPA1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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