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Article

C-terminal acidic cluster is involved in Ca2+-induced regulation of human transient receptor potential ankyrin 1 channel.

The Journal of biological chemistry - 25 May 2012

Sura Lucie, Zíma Vlastimil, Marsakova Lenka, Hynkova Anna, Barvík Ivan, Vlachova Viktorie

Abstract excerpt

The transient receptor potential ankyrin 1 (TRPA1) channel is a Ca(2+)-permeable cation channel whose activation results from a complex synergy between distinct activation sites, one of which is especially important for determining its sensitivity to chemical, voltage and cold stimuli. From the cytoplasmic side, TRPA1 is critically regulated by Ca(2+) ions, and this mechanism represents a self-modulating feedback...

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Source

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Identifiers

PMID: 22461626
DOI: 10.1074/jbc.M112.341859
PMCID: PMC3365772

Genes

TRPA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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C-terminal acidic cluster is involved in Ca2+-induced regulation of human transient receptor potential ankyrin 1 channel.PMID 22461626Read ↗

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