Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Thermosensory and nonthermosensory isoforms of Drosophila melanogaster TRPA1 reveal heat-sensor domains of a thermoTRP Channel.

Cell reports - 26 Jan 2012

Zhong Lixian, Bellemer Andrew, Yan Haidun, Ken Honjo, Jessica Robertson, Hwang Richard Y, Pitt Geoffrey S, Tracey W Daniel

Abstract excerpt

Specialized somatosensory neurons detect temperatures ranging from pleasantly cool or warm to burning hot and painful (nociceptive). The precise temperature ranges sensed by thermally sensitive neurons is determined by tissue-specific expression of ion channels of the transient receptor potential(TRP) family.We show here that in Drosophila, TRPA1 is required for the sensing of nociceptive heat. We identify two...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Gene Knockdown Techniques
Share to Hot Temperature

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Ion Channel Gating

Share to Ion Channels

Share to Nociceptors

Share to Patch-Clamp Techniques

Share to TRPA1 Cation Channel

Share to TRPC Cation Channels

Source

Open in PubMed Open full text

Identifiers

PMID: 22347718
DOI: 10.1016/j.celrep.2011.11.002
PMCID: PMC3278078

Genes

TRPA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Thermosensory and nonthermosensory isoforms of Drosophila melanogaster TRPA1 reveal heat-sensor domains of a thermoTRP Channel.PMID 22347718Read ↗

Residues in the pore region of Drosophila transient receptor potential A1 dictate sensitivity to thermal stimuli.Semantic proximity Read ↗

Caenorhabditis elegans TRPA-1 functions in mechanosensation.Semantic proximity Read ↗

Analysis of Drosophila TRPA1 reveals an ancient origin for human chemical nociception.Semantic proximity Read ↗

Convergent evolution of noxious heat sensing by TRPA5, a novel class of heat sensor in <i>Rhodnius prolixus</i>Semantic proximity Read ↗

A genome-wide Drosophila screen for heat nociception identifies α2δ3 as an evolutionarily conserved pain gene.Semantic proximity Read ↗

Disentangling Schwann Cell and Neuronal TRPA1 Function in Mouse Models of Familial Episodic Pain SyndromeSemantic proximity Read ↗

The anoctamin family channel subdued mediates thermal nociception in Drosophila.Semantic proximity Read ↗

Why individual thermo sensation and pain perception varies? Clue of disruptive mutations in TRPVs from 2504 human genome data.Semantic proximity Read ↗

TRPA1 gene variants hurting our feelings.Semantic proximity Read ↗

TRP channels.Semantic proximity Read ↗

Critical role of the pore domain in the cold response of TRPM8 channels identified by ortholog functional comparison.Semantic proximity Read ↗

Zebrafish TRPA1 channels are required for chemosensation but not for thermosensation or mechanosensory hair cell function.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.