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Advances in malignant hyperthermia: novel insights into heat-induced Ca2+ release as a thermal signaling.

Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi - 1 Jan 2025

Yamazawa Toshiko, Oyama Kotaro, Suzuki Madoka

Abstract excerpt

Thermoregulation is essential for maintaining homeostasis in mammals under various environmental conditions. Impairment of this function can result in severe conditions, such as fever, heat stroke, and malignant hyperthermia (MH). In this review, we will focus on the role of the type 1 ryanodine receptor (RYR1), a Ca2+ release channel that is crucial for excitation-contraction coupling in skeletal muscles....

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Body Temperature Regulation
Calcium
Calcium Signaling
Hot Temperature
Malignant Hyperthermia

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Muscle, Skeletal

Ryanodine Receptor Calcium Release Channel

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Open in PubMed Open full text

Identifiers

PMID: 40903240
DOI: 10.1540/jsmr.61.65
PMCID: PMC12418035

Genes

RYR1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Advances in malignant hyperthermia: novel insights into heat-induced Ca2+ release as a thermal signaling.PMID 40903240Read ↗

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