Article
Residues in the pore region of Drosophila transient receptor potential A1 dictate sensitivity to thermal stimuli.
The Journal of physiology - 1 Jan 2013
Wang Hong, Schupp Melanie, Zurborg Sandra, Heppenstall Paul A
Abstract excerpt
The capacity to sense temperature is essential for the survival of all animals. At the molecular level, ion channels belonging to the transient receptor potential (TRP) family of channels function as temperature sensors in animals across several phyla. TRP channels are opened directly by changes in temperature and show pronounced sensitivity at their activation range. To determine how temperature activates these...
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