Article
TRPV4-Rho GTPase complex structures reveal mechanisms of gating and disease.
Nature communications - 23 Jun 2023
Kwon Do Hoon, Zhang Feng, McCray Brett A, Feng Shasha, Kumar Meha, Sullivan Jeremy M, Im Wonpil, Sumner Charlotte J, Lee Seok-Yong
Abstract excerpt
Crosstalk between ion channels and small GTPases is critical during homeostasis and disease, but little is known about the structural underpinnings of these interactions. TRPV4 is a polymodal, calcium-permeable cation channel that has emerged as a potential therapeutic target in multiple conditions. Gain-of-function mutations also cause hereditary neuromuscular disease. Here, we present cryo-EM structures of...
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