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Article

Matrix stiffness mechanically conditions EMT and migratory behavior of oral squamous cell carcinoma

1 Jan 2018

Abstract excerpt

Tumors are composed of heterogeneous phenotypes, each having different sensitivities to the microenvironment. One microenvironment characteristic–matrix stiffness–helps regulate malignant transformation and invasion in mammary tumors, but its influence on oral squamous cell carcinoma (OSCC) is unclear. We observed that on stiff matrices, a highly invasive OSCC line with low E-cad/N-cad ratio (InvH/E:NL; SCC25)...

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PMID: 30559248
DOI: 10.1242/jcs.224360

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