Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Biomimetic Matrix Stiffness Modulates Hepatocellular Carcinoma Malignant Phenotypes and Macrophage Polarization through Multiple Modes of Mechanical Feedbacks.

ACS biomaterials science & engineering - 13 Jul 2020

Liu Xi-Qiu, Chen Xin-Ting, Liu Zhen-Zhen, Gu Sai-Sai, He Li-Jie, Wang Kai-Ping, Tang Rui-Zhi

Abstract excerpt

The extracellular matrix (ECM) stiffening is an important sign of local microenvironment change, which is considered as a hallmark of many diseases including hepatocellular carcinoma (HCC). The fates of both cancer cells and immune cells can be regulated by mechanical feedbacks acquired from ECM, but there is a lack of a precise study of mechanical feedback modes in different cell phenotypes following with the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biomimetics
Share to Carcinoma, Hepatocellular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cellular Mechanics and Interactions

Share to Feedback

Share to Liver Neoplasms

Share to Macrophages

Share to Phenotype

Share to Tumor Microenvironment

Source

Identifiers

PMID: 33463342
DOI: 10.1021/acsbiomaterials.0c00669

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Biomimetic Matrix Stiffness Modulates Hepatocellular Carcinoma Malignant Phenotypes and Macrophage Polarization through Multiple Modes of Mechanical Feedbacks.PMID 33463342Read ↗

Molecular Cues Guiding Matrix Stiffness in Liver FibrosisSemantic proximity Read ↗

Biophysics of Tumor Microenvironment and Cancer Metastasis - A Mini ReviewSemantic proximity Read ↗

Stiffness regulates dendritic cell and macrophage subtype development and increased stiffness induces a tumor-associated macrophage phenotype in cancer co-cultures.Semantic proximity Read ↗

Extracellular matrix remodeling in tumor progression and immune escape: from mechanisms to treatmentsSemantic proximity Read ↗

Principal mechanisms of extracellular matrix‐mediated cell–cell communication in physiological and tumor microenvironmentsSemantic proximity Read ↗

The Extracellular Matrix: Composition, Function, Remodeling and Its Role in Tumorigenesis<i></i>Semantic proximity Read ↗

The Extracellular Matrix: Its Composition, Function, Remodeling, and Role in TumorigenesisSemantic proximity Read ↗

Stiffness regulates dendritic cell and macrophage subtype development and increased stiffness induces a tumor-associated macrophage phenotype in cancer co-culturesSemantic proximity Read ↗

Heterogeneous matrix stiffness regulates the cancer stem-like cell phenotype in hepatocellular carcinoma.Semantic proximity Read ↗

Harnessing Extracellular Matrix Biology for Tumor Drug DeliverySemantic proximity Read ↗

Small extracellular vesicles promote stiffness-mediated metastasisSemantic proximity Read ↗

Influence of extracellular matrix composition on tumour cell behaviour in a biomimetic in vitro model for hepatocellular carcinomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.