Phenotypic delay in the evolution of bacterial antibiotic resistance: Mechanistic models and their implications.

Abstract excerpt

Phenotypic delay-the time delay between genetic mutation and expression of the corresponding phenotype-is generally neglected in evolutionary models, yet recent work suggests that it may be more common than previously assumed. Here, we use computer simulations and theory to investigate the significance of phenotypic delay for the evolution of bacterial resistance to antibiotics. We consider three mechanisms which...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Biological Evolution
• Share to Drug Resistance, Bacterial