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Article

Optimization of lag time underlies antibiotic tolerance in evolved bacterial populations.

Nature - 18 Sept 2014

Fridman Ofer, Goldberg Amir, Ronin Irine, Shoresh Noam, Balaban Nathalie Q

Abstract excerpt

The great therapeutic achievements of antibiotics have been dramatically undercut by the evolution of bacterial strategies that overcome antibiotic stress. These strategies fall into two classes. 'Resistance' makes it possible for a microorganism to grow in the constant presence of the antibiotic, provided that the concentration of the antibiotic is not too high. 'Tolerance' allows a microorganism to survive...

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PMID: 25043002
DOI: 10.1038/nature13469

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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