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Article

Modeling the impact of periodic bottlenecks, unidirectional mutation, and observational error in experimental evolution.

Journal of mathematical biology - 1 Jun 2005

Joyce Paul, Abdo Zaid, Ponciano José M, De Gelder Leen, Forney Larry J, Top Eva M

Abstract excerpt

Antibiotic resistant bacteria are a constant threat in the battle against infectious diseases. One strategy for reducing their effect is to temporarily discontinue the use of certain antibiotics in the hope that in the absence of the antibiotic the resistant strains will be replaced by the sensitive strains. An experiment where this strategy is employed in vitro produces data which showed a slow accumulation of...

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PMID: 15614551
DOI: 10.1007/s00285-004-0300-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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