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Article

Segregational drift hinders the evolution of antibiotic resistance on polyploid replicons.

PLoS genetics - 1 Aug 2023

Garoña Ana, Santer Mario, Hülter Nils F, Uecker Hildegard, Dagan Tal

Abstract excerpt

The emergence of antibiotic resistance under treatment depends on the availability of resistance alleles and their establishment in the population. Novel resistance alleles are encoded either in chromosomal or extrachromosomal genetic elements; both types may be present in multiple copies within the cell. However, the effect of polyploidy on the emergence of antibiotic resistance remains understudied. Here we...

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PMID: 37535631
DOI: 10.1371/journal.pgen.1010829
PMCID: PMC10399855

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