Associations between HLA class I and cytochrome P450 2C9 genetic polymorphisms and phenytoin-related severe cutaneous adverse reactions in a Thai population.

doi:10.1097/FPC.0000000000000211

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Article

Associations between HLA class I and cytochrome P450 2C9 genetic polymorphisms and phenytoin-related severe cutaneous adverse reactions in a Thai population.

Pharmacogenetics and genomics - 1 May 2016

Tassaneeyakul Wichittra, Prabmeechai Napat, Sukasem Chonlaphat, Kongpan Thachanan, Konyoung Parinya, Chumworathayi Pansu, Tiamkao Somsak, Khunarkornsiri Usanee, Kulkantrakorn Kongkiat, Saksit Niwat, Nakkam Nontaya, Satapornpong Patompong, Vannaprasaht Suda, Sangviroon Alisara, Mahasirimongkol Surakameth, Wichukchinda Nuanjun, Rerkpattanapipat Ticha, Tassaneeyakul Wongwiwat

Abstract excerpt

BACKGROUND: Phenytoin is one of the most common causative drugs of several types of severe cutaneous adverse reactions (SCAR) such as Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and drug reactions with eosinophilia and systemic symptoms (DRESS). Genetic polymorphisms of the human leukocyte antigens (HLA) and cytochromes P450 (CYP) have been proposed as key elements for the susceptibility to...

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PMID: 26928377
DOI: 10.1097/FPC.0000000000000211

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