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Article

Influence of genetic and non-genetic factors on phenytoin-induced severe cutaneous adverse drug reactions.

European journal of clinical pharmacology - 1 Jul 2017

Yampayon Kittika, Sukasem Chonlaphat, Limwongse Chanin, Chinvarun Yotin, Tempark Therdpong, Rerkpattanapipat Ticha, Kijsanayotin Pornpimol

Abstract excerpt

PURPOSE: The purpose of this study was to investigate the association of genetic factors including variants in HLA-B and CYP2C genes and non-genetic factors with phenotype-specific phenytoin (PHT)-induced severe cutaneous adverse reactions (SCARs) in Thai patients. METHODS: Thirty-six PHT-induced SCAR cases (15 Stevens-Johnson syndrome (SJS) and 21 drug rash with eosinophilia and systemic symptoms (DRESS)/drug...

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Source

Identifiers

PMID: 28391407
DOI: 10.1007/s00228-017-2250-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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