Risk and association of HLA with oxcarbazepine-induced cutaneous adverse reactions in Asians.

doi:10.1212/WNL.0000000000003453

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Article

Risk and association of HLA with oxcarbazepine-induced cutaneous adverse reactions in Asians.

Neurology - 3 Jan 2017

Chen Chun-Bing, Hsiao Yi-Hsin, Wu Tony, Hsih Mo-Song, Tassaneeyakul Wichittra, Jorns Teekayu P, Sukasem Chonlaphat, Hsu Chien-Ning, Su Shih-Chi, Chang Wan-Chun, Hui Rosaline Chung-Yee, Chu Chia-Yu, Chen Yi-Ju, Wu Ching-Ying, Hsu Chao-Kai, Chiu Tsu-Man, Sun Pei-Lun, Lee Hua-En, Yang Chin-Yi, Kao Pei-Han, Yang Chih-Hsun, Ho Hsin-Chun, Lin Jing-Yi, Chang Ya-Ching, Chen Ming-Jing, Lu Chun-Wei, Ng Chau Yee, Kuo Kang-Ling, Lin Chien-Yio, Yang Ching-Sheng, Chen Ding-Ping, Chang Pi-Yueh, Wu Tsu-Lan, Lin Yu-Jr, Weng Yi-Ching, Kuo Tseng-Tong, Hung Shuen-Iu, Chung Wen-Hung

Abstract excerpt

OBJECTIVE: To investigate the risk and genetic association of oxcarbazepine-induced cutaneous adverse reactions (OXC-cADRs), including Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN), in Asian populations (Chinese and Thai). METHODS: We prospectively enrolled patients with OXC-cADRs in Taiwan and Thailand from 2006 to 2014, and analyzed the clinical course, latent period, drug dosage, organ...

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PMID: 27913699
DOI: 10.1212/WNL.0000000000003453

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