Association of a SIRT1 polymorphism with changes of gray matter volume in patients with first-episode medication-naïve major depression.

doi:10.1016/j.pscychresns.2020.111101

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Article

Association of a SIRT1 polymorphism with changes of gray matter volume in patients with first-episode medication-naïve major depression.

Psychiatry research. Neuroimaging - 30 Jul 2020

Nan Dai, Yuqi Cheng, Zonglin Shen, Chenglong Dong, Na Li, Fang Liu, Cong Zhou, Xiufeng Xu

Abstract excerpt

A single nucleotide polymorphism (SNP) rs12415800 of the silent mating type information regulation 2 homolog 1 gene (SIRT1) has shown a genome-wide significant association with major depression disorder (MDD) in a recent GWAS using a large sample. Subsequent studies of SIRT1's biological functions were supportive of a possible role in the pathophysiology of MDD. However, SIRT1-mediated physiopathology of MDD may...

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PMID: 32447184
DOI: 10.1016/j.pscychresns.2020.111101

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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