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Article

The depression GWAS risk allele predicts smaller cerebellar gray matter volume and reduced SIRT1 mRNA expression in Chinese population.

Translational psychiatry - 9 Dec 2019

Liu Weipeng, Yan Hao, Zhou Danyang, Cai Xin, Zhang Yuyanan, Li Shiyi, Li Huijuan, Li Shiwu, Zhou Dong-Sheng, Li Xingxing, Zhang Chen, Sun Yan, Dai Jia-Pei, Zhong Jingmei, Yao Yong-Gang, Luo Xiong-Jian, Fang Yiru, Zhang Dai, Ma Yina, Yue Weihua, Li Ming, Xiao Xiao

Abstract excerpt

Major depressive disorder (MDD) is recognized as a primary cause of disability worldwide, and effective management of this illness has been a great challenge. While genetic component is supposed to play pivotal roles in MDD pathogenesis, the genetic and phenotypic heterogeneity of the illness has hampered the discovery of its genetic determinants. In this study, in an independent Han Chinese sample (1824 MDD...

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Identifiers

PMID: 31819045
DOI: 10.1038/s41398-019-0675-3
PMCID: PMC6901563

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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