Reduced gray matter brain volumes are associated with variants of the serotonin transporter gene in major depression.

doi:10.1038/mp.2008.62

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Article

Reduced gray matter brain volumes are associated with variants of the serotonin transporter gene in major depression.

Molecular psychiatry - 1 Dec 2008

Frodl T, Koutsouleris N, Bottlender R, Born C, Jäger M, Mörgenthaler M, Scheuerecker J, Zill P, Baghai T, Schüle C, Rupprecht R, Bondy B, Reiser M, Möller H-J, Meisenzahl E M

Abstract excerpt

The serotonergic system is involved in the pathophysiology of major depression as well as in the early central nervous system development and adult neuroplasticity. The aim of the study was to examine in 77 patients with major depression and 77 healthy controls the association between the triallelic polymorphism in the promoter region of the serotonin transporter gene (5-HTTLPR) and gray matter (GM) brain volumes...

Topics

Adult
Brain
Brain Mapping
DNA Mutational Analysis
Depressive Disorder, Major
Female
Gene Frequency
Genetic Predisposition to Disease
Genotype
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Magnetic Resonance Imaging

Male

Middle Aged

Polymorphism, Genetic

Psychiatric Status Rating Scales

Serotonin Plasma Membrane Transport Proteins

Source

Open in PubMed

Identifiers

PMID: 19008895
DOI: 10.1038/mp.2008.62

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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