Article
Expression Efficiency of Multiple Il9 Reporter Alleles Is Determined by Cell Lineage.
ImmunoHorizons - 21 May 2020
Kharwadkar Rakshin, Ulrich Benjamin J, Abdul Qayum Amina, Koh Byunghee, Licona-Limón Paula, Flavell Richard A, Kaplan Mark H
Abstract excerpt
Generation of allelic gene reporter mice has provided a powerful tool to study gene function in vivo. In conjunction with imaging technologies, reporter mouse models facilitate studies of cell lineage tracing, live cell imaging, and gene expression in the context of diseases. Although there are several advantages to using reporter mice, caution is important to ensure the fidelity of the reporter protein...
Topics
- Alleles
- Animals
- Cell Differentiation
- Cell Lineage
- Chromatin Immunoprecipitation
- Fluorescent Antibody Technique
- Immunity, Innate
- Mice
- Mice, 129 Strain
- Mice, Inbred BALB C
- Mice, Inbred C57BL
- Mice, Knockout
- Receptors, Interleukin-9