Article
Pulmonary overexpression of IL-9 induces Th2 cytokine expression, leading to immune pathology.
The Journal of clinical investigation - 1 Jan 2002
Temann Ulla-Angela, Ray Prabir, Flavell Richard A
Abstract excerpt
IL-9 is a pleiotropic cytokine with multiple functions on many cell types involved in the pathology of human asthma. The constitutive overexpression of IL-9 in the lungs of transgenic mice resulted in an asthma-like phenotype. To define the contribution of IL-9 to lung inflammation we generated transgenic mice in which lung-specific expression of the IL-9 transgene is inducible by doxycycline. Transgene induction...
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