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Article

A reporter mouse reveals lineage-specific and heterogeneous expression of IRF8 during lymphoid and myeloid cell differentiation.

Journal of immunology (Baltimore, Md. : 1950) - 15 Aug 2014

Wang Hongsheng, Yan Ming, Sun Jiafang, Jain Shweta, Yoshimi Ryusuke, Abolfath Sanaz Momben, Ozato Keiko, Coleman William G, Ng Ashley P, Metcalf Donald, DiRago Ladina, Nutt Stephen L, Morse Herbert C

Abstract excerpt

The IFN regulatory factor family member 8 (IRF8) regulates differentiation of lymphoid and myeloid lineage cells by promoting or suppressing lineage-specific genes. How IRF8 promotes hematopoietic progenitors to commit to one lineage while preventing the development of alternative lineages is not known. In this study, we report an IRF8-EGFP fusion protein reporter mouse that revealed previously unrecognized...

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Identifiers

PMID: 25024380
DOI: 10.4049/jimmunol.1301939
PMCID: PMC4119573

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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