Article
Phenotypic, transcriptomic, and spatial characterization of CD45RB+ naïve mature B cells: Implications in Sjögren's disease.
Clinical immunology (Orlando, Fla.) - 1 Nov 2024
Boudigou Marina, Frutoso Marie, Hémon Patrice, Le Dantec Christelle, Chatzis Loukas, Devauchelle Valérie, Jamin Christophe, Cornec Divi, Pers Jacques-Olivier, Le Pottier Laëtitia, Hillion Sophie
Abstract excerpt
The conventional classification of mature B cells overlooks the diversity within IgD+ CD27- naïve B cells. Here, to identify distinct mature naïve B cells, we categorized CD45RBMEM55- B cells (NA RB-) and CD45RBMEM55+ B cells (NA RB+) and explore their function and localization in circulation and tissues under physiological and pathological conditions. NA RB+ B cells, found in secondary lymphoid organs,...
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