Article

Deciphering B cell Maturation Dynamics in Hyper IgM Syndromes

2026-03-09

Abstract excerpt

<title>Abstract</title> <p> <bold>Purpose:</bold> Hyper-IgM syndromes (HIGM) are primary immunodeficiencies characterized by defective class-switch recombination (CSR) and impaired humoral immunity. While genetic causes such as CD40L and AICDA mutations are well-established, a detailed comparison of B cell maturation dynamics across different HIGM subtypes remains limited. This study aims to comprehensively cha...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 51b8c7f4-f324-5925-a979-e6c91dca235d
DOI: 10.21203/rs.3.rs-8894623/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Deciphering B cell Maturation Dynamics in Hyper IgM SyndromesDOI 10.21203/rs.3.rs-8894623/v1Read

Clinical Phenotypes of Hyper-IgM Syndromes.Semantic proximity Read

Hyper-immunoglobulin M syndromes caused by intrinsic B-lymphocyte defects.Semantic proximity Read

Hyper immunoglobulin M syndrome due to CD40 deficiency: clinical, molecular, and immunological features.Semantic proximity Read

Hypomorphic RAG2 Deficiency Promotes Selection of Self-Reactive B Cells.Semantic proximity Read

CD40-CD40L independent Ig gene hypermutation suggests a second B cell diversification pathway in humans.Semantic proximity Read

Clinical features and genetic analysis of Taiwanese patients with the hyper IgM syndrome phenotype.Semantic proximity Read

Update on the hyper immunoglobulin M syndromesSemantic proximity Read

Differential Expression of IgM and IgD Discriminates Two Subpopulations of Human Circulating IgM+IgD+CD27+ B Cells That Differ Phenotypically, Functionally, and Genetically.Semantic proximity Read

Clinical, immunological, and molecular characterization of hyper-IgM syndrome due to CD40 deficiency in eleven patients.Semantic proximity Read

Class-Switch Recombination (CSR)/Hyper-IgM (HIGM) Syndromes and Phosphoinositide 3-Kinase (PI3K) DefectsSemantic proximity Read

Clinical and laboratory findings in hyper-IgM syndrome with novel CD40L and AICDA mutations.Semantic proximity Read

Immunoglobulin class‐switch recombination: Mechanism, regulation, and related diseasesSemantic proximity Read