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Article

Genetic and epigenetic intratumor heterogeneity impacts prognosis of lung adenocarcinoma.

Nature communications - 18 May 2020

Hua Xing, Zhao Wei, Pesatori Angela C, Consonni Dario, Caporaso Neil E, Zhang Tongwu, Zhu Bin, Wang Mingyi, Jones Kristine, Hicks Belynda, Song Lei, Sampson Joshua, Wedge David C, Shi Jianxin, Landi Maria Teresa

Abstract excerpt

Intratumor heterogeneity (ITH) of genomic alterations may impact prognosis of lung adenocarcinoma (LUAD). Here, we investigate ITH of somatic copy number alterations (SCNAs), DNA methylation, and point mutations in lung cancer driver genes in 292 tumor samples from 84 patients with LUAD. LUAD samples show substantial SCNA and methylation ITH, and clonal architecture analyses present congruent evolutionary...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32424208
DOI: 10.1038/s41467-020-16295-5
PMCID: PMC7235245

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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