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Article

Pontin-deficiency causes senescence in fibroblast cells and epidermal keratinocytes but induces apoptosis in cancer cells.

Biochimica et biophysica acta. Molecular cell research - 1 Sept 2020

Park Koog Chan, Park Joo Hyeon, Baek Sung Hee, Kim Keun Il

Abstract excerpt

Pontin, a member of the AAA+ ATPase family, plays important roles in a variety of cellular processes, including transcription regulation, DNA damage response, telomerase activity, and cellular transformation. In the previous studies, Pontin deletion in mice was lethal to embryos. Here, we demonstrate that the depletion of Pontin induced cellular senescence in mouse and human fibroblasts as well as in mouse...

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Identifiers

PMID: 32417257
DOI: 10.1016/j.bbamcr.2020.118740

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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