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PLA2R1 promotes DNA damage and inhibits spontaneous tumor formation during aging

16 Feb 2021

Abstract excerpt

Although aging is a major risk factor for most types of cancers, it is barely studied in this context. The transmembrane protein PLA2R1 (phospholipase A2 receptor) promotes cellular senescence, which can inhibit oncogene-induced tumor initiation. Functions and mechanisms of action of PLA2R1 during aging are largely unknown. In this study, we observed that old Pla2r1 knockout mice were more prone to spontaneously...

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PMID: 33594040
DOI: 10.1038/s41419-021-03468-3

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