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Epigenetic Regulation of Skin Cells in Natural Aging and Premature Aging Diseases

12 Dec 2018

Abstract excerpt

Skin undergoes continuous renewal throughout an individual's lifetime relying on stem cell functionality. However, a decline of the skin regenerative potential occurs with age. The accumulation of senescent cells over time probably reduces tissue regeneration and contributes to skin aging. Keratinocytes and dermal fibroblasts undergo senescence in response to several intrinsic or extrinsic stresses, including...

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PMID: 30545089
DOI: 10.3390/cells7120268

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