Article
Senescence-Like Phenotypes in Human Nevi.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2017
Joselow Andrew, Lynn Darren, Terzian Tamara, Box Neil F
Abstract excerpt
Cellular senescence is an irreversible arrest of cell proliferation at the G1 stage of the cell cycle in which cells become refractory to growth stimuli. Senescence is a critical and potent defense mechanism that mammalian cells use to suppress tumors. While there are many ways to induce a senescence response, oncogene-induced senescence (OIS) remains the key to inhibiting progression of cells that have acquired...
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