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DNA damage response and GATA4 signaling in cellular senescence and aging-related pathology

13 Sept 2022

Abstract excerpt

Aging is the continuous degradation of biological function and structure with time, and cellular senescence lies at its core. DNA damage response (DDR) can activate Ataxia telangiectasia-mutated serine/threonine kinase (ATM) and Rad3-related serine/threonine kinase (ATR), after which p53 activates p21, stopping the cell cycle and inducing cell senescence. GATA4 is a transcription factor that plays an important...

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PMID: 36177479
DOI: 10.3389/fnagi.2022.933015

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